What is Viral Inactivation?

Описание: In this video, we dive into the importance of viral inactivation in downstream bioprocessing. As the demand for biologics continues to grow, ensuring the safety and purity of these products is crucial. Viral inactivation is a critical step in the purification process, and with the right technology, it can be achieved efficiently and effectively.

Viral inactivation is the first of usually two dedicated steps designed to enhance viral safety of biotherapeutic products. During inactivation, any virus present within the pooled and semi-purified therapeutic suspension is intentionally destroyed or abruptly rendered non-pathogenic, usually by altering the environment around the virus to cause irreversible disruption and denaturation of the viral structure.

Typically, this is done by altering the environment around the virus to cause irreversible disruption and denaturation of the viral structure – e.g., through chemical, physical, or even energetic methods. Virus removal is separate and distinct from viral inactivation as it is a complementary process that further enhances viral safety by eliminating or separating the virus from the protein(s) or products of interest.

Learn more about viral inactivation: http://bit.ly/3jnoPsl

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