Molecular structure of BZR1-BAM8 - non-catalytic beta amylase domain (from corn)
Автор: The Shabek Structural Biology Laboratory - UC Davis
Загружено: 2022-08-17
Просмотров: 88
Описание:
Plant β-Amylase (BAM) proteins have critical roles in growth, development, stress response, and hormone regulation.
The noncatalytic BAM7/8 contain N-terminal BZR1 domains and were shown to be involved in the regulation of brassinosteroid signaling and possibly serve as sensors of yet an uncharacterized metabolic signal. In a recent paper by Drs Fuai Sun, Malathy Palayam and Nitzan Shabek from the Shabek Lab at the University of California Davis (Biological Sciences - Plant Biology Dept.) determined the crystal structure of Zea mays BZR1-type BAM8 and provided comprehensive insights into its noncatalytic adaptation. This study adds a new layer of understanding to starch breakdown mechanism and elucidates the acquired adjustments of noncatalytic BZR1-type BAMs in plants.
Reference: Sun et al., 2022. Journal of Structural Biology
https://www.sciencedirect.com/science...
The Shabek lab is supported by National Science Foundation (NSF Awards: #2047396, #2028283, and #2139805), UC Davis Academic Senate and other internal awards.
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