The Sleeper Bacteria: The Biochemistry of Antibiotic Persistence
Автор: g Fun Facts online
Загружено: 2026-01-11
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This episode delves into the fascinating world of 'persister cells,' dormant bacteria that survive antibiotic treatment by entering a state of suspended animation. Unlike resistant bacteria, persisters are not genetically altered but phenotypically dormant, making them impervious to antibiotics that target active cellular processes. Discovered in 1944 by Joseph Bigger, these 'sleeper' bacteria are now understood to be the root cause of chronic infections like Lyme disease, cystic fibrosis, and tuberculosis, as they can lie dormant for years before reactivating. The episode explores the intricate biochemical mechanisms, including Toxin-Antitoxin systems and the 'magic spot' alarmone, that enable this survival strategy. It also highlights new therapeutic approaches aimed at either killing persisters in their dormant state or forcing them to wake up and become vulnerable, offering hope for overcoming infections that have long defied conventional treatment.
https://gfunfacts.online/article/c39c...
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