Long Haul COVID-19: Low DHEA Impairs Your Recovery

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DHEA is a hormone made primarily by the adrenal glands and gonads (testicles and ovaries) but is also made in the brain and skin.

DHEA may have an exceptionally important role to play in managing recovery from COVID-19.
It’s the most essential and abundant steroid hormone, and under the right conditions, the body converts DHEA into sex hormones, such as testosterone and estrogen, helping to keep everything in balance.

COVID-19 has been shown to cause lasting damage to the heart and blood vessels. DHEA plays a vital role in cardiovascular health by supporting nitric oxide production, regulating vascular tone, and influencing cholesterol and blood pressure.

Beyond cardiovascular effects, COVID-19 can also drive persistent inflammation, which negatively affects both cognitive function and emotional well-being.

Fatigue and weakness are frequently reported — not only during infection and long-haul recovery but also among individuals with autoimmune conditions.
For individuals with Hashimoto’s disease, an autoimmune disorder of the thyroid, DHEA plays a crucial role in converting the inactive thyroid hormone T4 into its active form, T3, which every cell relies on for energy.
Elevated cortisol interferes with this conversion, but adequate DHEA can help lower cortisol levels and restore balance.

Many clinicians who are working with long hauelers have found low DHEA on testing. Clinical research suggests that DHEA supplementation improves “adrenal fatigue” and brain fog because healing requires energy, restoring vitality is a crucial step in recovery.
Research supports this perspective.

One study measuring DHEA and its metabolite, DHEA-sulfate, after infection or injury found that cortisol levels continued to rise while DHEAS declined, peaking two weeks later. Even after six months, DHEAS levels had not fully returned to baseline. These findings highlight why replenishing DHEA to restore energy reserves makes practical sense.

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