Precision Dosing Using PBPK Modeling
Автор: Certara
Загружено: 2016-03-25
Просмотров: 5718
Описание:
Precision dosing― the right dose, for the right patient, at the right time― is crucial to providing patients with the most efficacious medications with minimal probability of adverse events. One key step towards achieving the delivery of individualized dosing is testing potential dosing regimens in a patient's 'virtual twin.' The other key step is to have as much drug information as possible. Achieving these key steps requires generating a large amount of data. A computer modeling and simulation platform is needed to assimilate these data together to study their interactions.
Some clinical trials only reveal the “average response” to a drug in a particular population. Yet, individual responses of patients can vary significantly due to their genetics, physiology and ethnicity. In a systems pharmacology paradigm, the Certara framework of physiologically based pharmacokinetic (PBPK) models integrates patient characteristics and drug parameters and predicts the drug pharmacokinetics properties using in vitro- in vivo extrapolation (IVIVE) techniques.
Learn how PBPK models and IVIVE can be used as tools for precision dosing. Dr. Devendra Pade discussed key differences between ethnic groups and diseased populations versus healthy individuals and illustrate how these differences affect drug pharmacokinetics.
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