Comparative genome mapping

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Comparative genomics is the study of the relationship of genome structure and function across different biological species or strains. Comparative genomics is an attempt to take advantage of the information provided by the signatures of selection to understand the function and evolutionary processes that act on genomes. While it is still a young field, it holds great promise to yield insights into many aspects of the evolution of modern species. The sheer amount of information contained in modern genomes (3.2 gigabases in the case of humans) necessitates that the methods of comparative genomics are automated. Gene finding is an important application of comparative genomics, as is discovery of new, non-coding functional elements of the genome.

Comparative Genomics is based on the genome mapping and sequencing, comparing structure of known genes and genome, to understand the gene function, mechanism of the expression and the evolution of species. Using the homology of the sequence and structure in coding which between human genome and model organism genome, to clone human disease genes, revealing mechanisms on gene function and disease molecular to clarify evolution relationship and the inner structure of the genome.