Lattice vs Granular Corneal Dystrophy: Spot the Difference at the Slit Lamp

Описание: In this high-yield video, we simplify the TGFBI-related stromal corneal dystrophies — focusing on Granular Corneal Dystrophy (GCD1, GCD2/Avellino) and Lattice Corneal Dystrophy (LCD1).

🔬 Key Concepts Covered:
• Genetics: TGFBI mutations (R555W in GCD1, Arg124His in GCD2, R124L in GCD3, LCD1 variants)
• Pathology: Hyaline (Masson trichrome+) vs Amyloid (Congo red+, apple-green birefringence)
• Clinical: Slit-lamp signs, recurrent erosions, age of onset, disease progression
• Diagnostics: Confocal & AS-OCT depth, histology, IC3D classification
• Management: PTK, DALK, PK outcomes, recurrence, refractive surgery contraindications (LASIK/SMILE)

📍 Perfect for: Ophthalmology students, FRCS / FICO candidates, cornea specialists, and vision researchers.

⚠️ Clinical Pearl: Always screen for TGFBI mutations before keratorefractive surgery to prevent post-LASIK exacerbation in GCD2/Avellino dystrophy.

📚 References: Kanski, The “Cornea E-Book” edited by Jay H. Krachmer, Mark J. Mannis, and Edward J. Holland
EyeWiki, PubMed & major corneal dystrophy reviews.

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