Cortisol & Glucocorticoids Part 2 of 3: Biochemistry, Structure, SAR & Drug Design
Автор: Patricia Flatt
Загружено: 2026-02-13
Просмотров: 18
Описание:
How do small structural changes to cortisol dramatically alter drug potency and side effects?
In Part 2, we move from receptor biology into medicinal chemistry. We analyze cortisol’s structure and explore structure–activity relationships (SAR) that drive potency, selectivity, duration of action, and therapeutic use.
Topics covered:
Structure of cortisol
Key functional groups and steroid backbone
Structure–Activity Relationships (SAR)
How synthetic glucocorticoids are modified
Cortisol-based drugs
Prednisone: prodrug activation and clinical use
Why steroid tapering is essential
Mechanism-based explanation of side effects
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