Rolf Fronczek, PhD, MD: Narcolepsy and Opiates

Описание: Rolf Fronczek, PhD, MD, Department of Neurology, Leiden University Medical Centre, Sleep-Wake Centre SEIN, sat with NeurologyLive at the 24th Congress of the European Sleep Research Society in Basel, Switzerland, to discuss the connection between narcolepsy and opiates.

In a collaboration with researchers from UCLA, Fronczek and colleagues examined a number of hypocretin neurons in postmortem brains and found that some individuals presented with an unexpectedly large cell number increase. Looking back, researchers discovered that those patients were opiate addicts. Similar increases in hypocretin-producing cells were induced in a mouse model by administration of morphine.

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