Fatemeh Geranmayeh | Monitoring technology for deep phenotyping of cognitive impairment after stroke

Описание: Abstract
Stroke remains one of the leading causes of death and disability worldwide, affecting over 12 million people annually and leaving many survivors with lasting cognitive and communicative impairments. Accurate, scalable monitoring of post-stroke cognitive function is critical for understanding recovery trajectories and optimizing rehabilitation, yet traditional assessments are infrequent, resource-intensive, and poorly suited to capturing day-to-day fluctuations.

I will present an online monitoring platform for deep phenotyping of cognitive impairment after stroke, integrating unsupervised digital tasks, frequently captured behavioural measures, and speech analysis to map subtle changes in cognition over time. This framework enables high-resolution characterization of individual recovery profiles and reveals digital biomarkers that align with established neuropsychological outcomes.

I will discuss how we can leverage foundation models for speech-to-text modelling, specifically, developing and fine-tuning speech-to-text and language models to detect pathological speech patterns in patients with stroke. Together, these efforts outline a pathway toward frequent, data-driven phenotyping of post-stroke recovery and early detection of cognitive decline.

Fatemeh Geranmayeh
Dr. Fatemeh Geranmayeh is a Clinician Scientist at the Department of Brain Sciences, Imperial College London. She leads the Clinical Language & Cognition Group, focusing on post-stroke language and cognitive impairments, vascular dementia, and the deep cognitive and clinical phenotyping of patients with cerebrovascular disease. Dr. Geranmayeh's academic journey began in 2004 when she earned a First Class Honours BSc degree in Neuroscience, receiving the Goldberg-Schachmann and Freda Becker Award from the University of London. She completed her medical degree in 2006 and pursued a PhD under the mentorship of the late Professor Richard Wise, which she completed in 2015.

Her research employs advanced neuroimaging techniques to investigate the neural mechanisms underlying speech production recovery following acute stroke. In 2022, she initiated the IC3 study, a multimodal clinical study to track longitudinal cognitive and language recovery post-stroke, incorporating novel blood biomarkers, brain imaging, and automated speech recognition and cognitive assessments.

In addition to her research, Dr. Geranmayeh is a practicing neurology consultant, running a specialist vascular cognitive clinic, and co-Director of the Alzheimer's Society VIDA (Vascular and Immune contributors to Dementia) Doctoral Training Centre.