Autoantibodies as Biomarkers in Immuno-Oncology

Описание: During Labroots' Drug Discovery & Development virtual conference, Hans-Dieter Zucht presented how autoantibodies can be used as biomarkers in immuno-oncology research.

In this presentation, we will discuss how autoantibody (AAB) profiling using the bead-based multiplex Luminex Technology combined with machine-learning procedures offers a unique tool for biomarker research. Our SeroTag platform has been developed for quantifying the serum anti-tumour and auto-antibody reactivities towards customized and pre-validated panels of protein and peptide antigens (ImmunoINSIGHT by Oncimmune®). The highly dimensional data can be used to extract predictive models, identify biomarkers, create patient subgroups and also characterize regulatory networks involving cytokine and receptors suggesting that autoantibodies actively participate in immune regulation. Case studies for applications in melanoma CPI treatment and other cancers will be discussed.

Learning objectives of this presentation include:
Autoantibodies are relevant immunological biomarkers
As autoantibodies can also target cytokines, receptors they are involved in immune regulation
Autoantibody multiplexing and individual assays can be deployed during clinical research

Learn more: https://www.luminexcorp.com/xmap-tech...