JAK2, CALR, and MPL Mutations Advanced Treatment Strategies That Work । GlobalRPh

Описание: JAK2, CALR, and MPL Mutations: Advanced Treatment Strategies That Work | GlobalRPh

Welcome to the GlobalRPh YouTube Channel — your trusted source for in-depth, evidence-based hematology and oncology education.

👉[Check out our video library on GlobalRPh: https://globalrph.com/globalrph-video... ]
Blog Article: https://globalrph.com/2025/05/jak2-ca...

In this expert-level lecture, we explore the molecular mechanisms and treatment strategies for myeloproliferative neoplasms (MPNs) driven by JAK2V617F, CALR exon 9, and MPL W515 mutations. Learn how these mutations shape diagnosis, prognosis, and therapeutic decision-making, and discover emerging treatments that are changing outcomes for MPN patients.

🔬 Topics Covered in This Video:
✅ How JAK2, CALR, and MPL mutations drive MPN pathogenesis
✅ Diagnostic tools: allele burden, mutation order, and NGS
✅ Current therapies: JAK inhibitors (Ruxolitinib, Fedratinib, Momelotinib) & Interferon-alpha
✅ New and emerging treatments: CALR-targeted monoclonal antibodies, peptide vaccines, clinical trials
✅ Personalized treatment & mutation-guided risk stratification
✅ Strategies to manage treatment resistance in MPNs

🎯 Who Should Watch?
This content is ideal for:
• Hematologists & Oncologists
• Clinical Pharmacists
• Medical Residents & Fellows
• Researchers in Molecular Oncology
• Science-curious medical professionals

🧬 Stay Ahead in Precision Medicine
Subscribe and turn on the bell 🔔 to stay updated on the latest advances in hematology, oncology, and precision therapies.
Have thoughts or questions? Drop them in the comments — we’d love to hear from you!

📌 Chapters:
00:00:00 Welcome to GlobalRPh
00:00:28 MPN Mutations Overview
00:01:39 Molecular Drivers of MPN
00:02:38 Triple-Negative MPNs & Testing
00:03:17 Diagnosis and Next-Gen Sequencing
00:04:02 JAK2-Targeted Therapies
00:05:04 CALR/MPL-Specific Therapies
00:05:51 MPL Mutations & Clinical Trials
00:07:09 Precision Medicine in MPNs
00:08:21 CALR Sequencing & Outcomes
00:09:13 Future of MPN Treatment
00:09:42 Outro and Thank You

#MPN #JAK2Mutation #CALR #MPL #Ruxolitinib #HematologyEducation #GlobalRPh #PrecisionMedicine #Myelofibrosis #PolycythemiaVera #EssentialThrombocythemia #OncologyEducation #JAK2Mutation #CALRMutation #MPLMutation
#MPN #MyeloproliferativeNeoplasms #MPNTreatment #Ruxolitinib #Fedratinib
#Momelotinib #CALRTherapy #MPNResearch