NAD Boosting Supplement Helps Long-COVID Symptoms! Not So Fast My Friends...

Описание: Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial

 DOI: 10.1016/j.eclinm.2025.103633

Long-COVID, a condition manifesting after COVID infection in approximately 7% of individuals, is characterized by non-specific symptoms such as fatigue, cognitive deficits, headache, myalgias, and mood changes. These symptoms may persist for months to even years after the acute phase of the infection. Proposed mechanisms for long-COVID include immune dysregulation, mitochondrial dysfunction, oxidative stress, and disruptions in metabolism. COVID infection dysregulates NAD pathways, increasing NAD consumption and depletion. NAD is important for energy metabolism, DNA repair, and immune system regulation.

This 24-week study compared 20 weeks of NR supplementation (250 mg four times a day) to (NR-NR group) to 10 weeks of placebo followed by a switch to NR (PBO-NR). NAD levels increased by 2.1 fold at 20 weeks in the NR-NR group and remained stable in the PBO-NR group during the PBO phase and rose by 2.1 fold at 10 weeks once switched to NR. There were no between-group or within-group changes in cognitive score testing, fatigue severity, sleep quality, and symptoms of anxiety and depression.

In a post-hoc analysis where all participants who completed 10 weeks of NR therapy were grouped, there were significant within-group improvements in fatigue, sleep quality, and depression symptoms. NAD level increases were associated with improved perceived sleep quality. No serious adverse events were related to NR; however, muscle cramps, nausea, bruising, flushing, rash, and vertigo were possibly related to NR supplementation.

Limitations - Exploratory analysis, high drop-out rates (51.4% NR-NR vs 28.6% placebo-NR), low number of patients (58 patients), funded by Niagen (maker of NR supplement), two authors have equity in Niagen

#nimbushealthcare #doctor #physician #pharmacist #health #wellness #lifestyle #COVID #Niagen #NAD #NR #supplements