MRSEC Seminar: Cytoskeleton dynamics and function across domains of life (Alexandre Bisson)
Автор: Brandeis MRSEC
Загружено: 2020-05-11
Просмотров: 130
Описание: Cytoskeletal polymers control the assembly of cellular structures and transport cargo in virtually all known living organisms. Despite their ubiquitous function, these self-assembled powerhouses come in a variety of flavors in terms of sizes, structures, and kinetic properties. In this talk, I will walk through my past and present work on the relationship between the dynamics and cellular function of cytoskeletal systems throughout evolution. Using single-molecule tracking in live cells, I will discuss the mechanisms in which tubulin-like polymers control cell division in bacteria. To further understand how these bacterial filaments evolved to eukaryotic microtubules, my group studies the functions and properties of multiple tubulins in archaea, the last prokaryotic common ancestor of eukaryotes. Interestingly, we see the presence of both eukaryotic-like and bacterial-like tubulin systems, suggesting the first eukaryotes likely comprised prokaryotic traits. We anticipate our results will unveil unprecedented information about self-assembly regimes and the emergency of new biophysical features in cells.
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