Deimination restores inner retinal visual function in murine demyelinating disease

Описание: Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a posttranslational protein modification, in retinal function. Highlights:

Highlights:
Demyelinating diseases, including multiple sclerosis, are frequently accompanied by vision loss.
Deimination is a protein modification that is impaired in the retinas of patients with demyelinating disease.
Using a rat model of demyelinating disease, the researchers demonstrated that loss of deimination impaired retinal function.
Restoration of deimination restored neurite outgrowth and retinal function, suggesting that deimination could be a therapeutic target.

Article: http://www.jci.org/articles/view/64811